Material-Selective Deposition of Reactive Group-Functionalized Poly‑l‑lysine for DNA Sensing at Optical Waveguides.

ABSTRACT: Precise localization of biomarkers within the sensing area of biosensors is crucial for enhancing performance and minimizing analyte loss to nonsensing regions. Commercial material-selective coatings enable site-specific biofunctionalization but are typically constrained by limited reactive chemistries, reducing their versatility and controllability. We present a selective coating strategy based on a poly-l-lysine (PLL) scaffold that retains the material-selective properties of a commercial carboxylic acid (COOH)-based coating for a Si₃N₄ waveguide with a poly-(ethylene glycol) (PEG)-covered SiO₂ surrounding while enabling modular surface functionalization. The PLL scaffold was functionalized with controlled grafting densities of oligo-(ethylene glycol) (OE

SUBMITTER: Aphrham S 

PROVIDER: S-EPMC12676348 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature