Synergistic chemodynamic and metabolic reprogramming-based cancer therapy by CuO@HA nanozymes with oxygen vacancy.

ABSTRACT: Rationale: The tumor microenvironment (TME), which is characterized by disordered metabolism, acidic pH, and high glutathione (GSH) and hydrogen peroxide (H₂O₂) levels, seriously hampers the efficacy of cancer therapy. Nanozymes with multi-enzyme activity have considerable potential to reprogram the TME and suppress tumor growth. Methods: A strategy for remodulating the TME based on a hierarchical CuO nanozyme with oxygen vacancies decorated with hyaluronic acid (HA) (CuO@HA) was developed. The enzyme activities of CuO@HA were evaluated by enzyme kinetic assays and density functional theory (DFT). The in vitro and in vivo anti-tumor effects were estimated, and the mechanism was explored using multi-omic methods. Results: CuO@HA exhib

SUBMITTER: Wang W 

PROVIDER: S-EPMC12679366 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature