Comparative immunoinformatic analysis of Rhipicephalus microplus cocktail vaccine targets.

ABSTRACT:

Background

The cattle fever tick, Rhipicephalus microplus, is found in tropical and subtropical regions worldwide. Infestations of this tick lead to significant economic losses for cattle producers and dairy farmers, and the ticks can transmit a variety of pathogens that cause diseases such as babesiosis, anaplasmosis and theileriosis. The proteins Bm86, AQP1, AQP2 and VgR are expressed in various tick tissues, including the gut, salivary glands and ovaries. These proteins regulate essential physiological processes, including water balance (AQP1, AQP2), reproduction (VgR) and cell membrane integrity (Bm86).

Methods

Comprehensive bioinformatic and immunoinformatic analyses were conducted to evaluate Bm86, AQP1, AQP2 and VgR as potential vaccine targets against R. microplus. S

SUBMITTER: Hendawy SHM 

PROVIDER: S-EPMC12690872 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature