Annotating the x-ray diffraction pattern of vertebrate striated muscle.

ABSTRACT: Low-angle x-ray diffraction is a powerful technique for analyzing the molecular structure of the myofilaments of striated muscle in situ. It has contributed greatly to our understanding of the relaxed, 430-Å repeating organization of myosin heads in thick filaments in skeletal and cardiac muscle. Using x-ray diffraction, changes in filament structure can be detected on the angstrom length scale and millisecond timescale, leading to models that are the foundation of our understanding of the structural basis of contraction. As with all x-ray fiber diffraction studies, interpretation requires modeling, which has previously been based on low-resolution knowledge of thick filament structure and is complicated by the contributions of multiple filament components to most x-ray reflections. Here,

SUBMITTER: Koubassova NA 

PROVIDER: S-EPMC12694897 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature