Polygenicity and APOE ε4 shape response to intervention in mild cognitive impairment.

ABSTRACT:

Background

Multidomain lifestyle interventions have shown effectiveness in preventing dementia, but identifying high-risk groups most likely to benefit remains unclear.

Methods

We re-evaluated the SUPERBRAIN-MEET multidomain intervention study in mild cognitive impairment (MCI) patients, incorporating polygenic risk scores (PRS) for Alzheimer's disease and APOE ε4 status using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) total index as the primary outcome.

Results

Both intervention and control groups showed cognitive improvement over 24 weeks, with greater gains in the intervention arm. Relative intervention efficacy (RIE) increased with higher genetic risk, being most pronounced among APOE ε4 carriers and individuals with high PRS. When

SUBMITTER: Hwang J 

PROVIDER: S-EPMC12699802 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature