Individual paraventricular hypothalamic GLP-1R neurons track ingestion across energy states.

ABSTRACT: Energy homeostasis is tightly regulated to ensure metabolic health in uncertain environments. Neurons expressing the glucagon-like peptide-1 receptor (GLP-1R) contribute to maintaining body weight, but how their activity is regulated according to energy state remains unclear. Here, we investigated the function and cellular dynamics of GLP-1R-expressing neurons of the paraventricular hypothalamus (PVH^GLP-1R) during food consumption, providing strong evidence of their ability to bidirectionally control feeding. Elevating intracellular signaling through 3',5'-cyclic adenosine monophosphate (cAMP), the major pathway downstream of GLP-1R, suppressed feeding. Using two-photon calcium imaging, we observed heterogeneous single-cell responses to ingestion that occurred regardless of ener

SUBMITTER: Savani RH 

PROVIDER: S-EPMC12704261 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature