Anatomical Progression of Neuropathology in FTLD-TDP Type C and Linkage to Annexin A11.

ABSTRACT:

Objective

Frontotemporal lobar degenerations (FTLD)-TDP type C (TDP-C) is distinguished from other FTLD-TDP subtypes by 3 unique features: (1) invariable onset in the anterior temporal lobe (ATL), (2) phosphorylated TDP-43 (pTDP) neurites in cortex, and (3) colocalization of all pTDP deposits with annexin A11 (ANXA11). This article provides a whole-brain anatomical account of TDP-C disease progression in relation to clinical, imaging, and neuropathologic patterns.

Methods

Thirty-two cases with TDP-C were studied, including neuropathologic findings and longitudinal magnetic resonance imaging. In 6 of these cases, cortical and subcortical areas were analyzed using whole hemisphere sections. Five control cases were used for comparison.

Results

Progression was reconstruct

SUBMITTER: Kawles A 

PROVIDER: S-EPMC12704552 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature