The DSG1-AS1/miR-125b-5p/HMGA2 axis is associated with the formation of neutrophil extracellular traps in atopic dermatitis.

ABSTRACT:

Background

As a chronic inflammatory skin disease, atopic dermatitis (AD) results from immune dysregulation, epidermal barrier dysfunction, and inflammatory microenvironment. Although long non-coding RNAs (lncRNAs) and neutrophil extracellular traps (NETs) are implicated in inflammatory diseases, the role of the DSG1-AS1/miR-125b-5p/HMGA2 axis in AD and its link to NETs formation remain unclear.

Objective

This research sought to explore the role of the DSG1-AS1/miR-125b-5p/HMGA2 axis in AD pathogenesis, focusing on its regulation of keratinocyte inflammation, neutrophil recruitment, and NETs formation, and evaluate its potential as a diagnostic biomarker.

Methods

The expression levels of DSG1-AS1, miR-125b-5p and HMGA2 were detected by real-time quantitative PCR (RT-q

SUBMITTER: Wang H 

PROVIDER: S-EPMC12706904 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature