Cutaneous signs of insulin resistance with central obesity: insights into adipocentric metabolic dysfunction in South Asians.

ABSTRACT:

Aim and objectives

To investigate the Cutaneous Signs of Insulin Resistance, namely acanthosis nigricans (AN) and acrochordon (AC), in individuals with Central Obesity (CO-CSIR) as physical predictors of metabolic syndrome (MetS), underlying adipose tissue pathology, and consequent pathophysiological traits in South Asians.

Methods

In this study, 371 participants were recruited in a tertiary care facility and grouped based on the presence of cutaneous signs (AC and/or AN) and central obesity. Each participant was assessed for MetS, T2D, as well as other demographic, biochemical, and radiological parameters. Additionally, we conducted transcriptome profiling in adipose depots for selected individuals to investigate whether there are m

SUBMITTER: Saxena A 

PROVIDER: S-EPMC12708322 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature