Real-ambient PM_2.5 exposure disrupts hematopoietic homeostasis via HIF-1α-driven myeloid skewing and promotes organ inflammation.

ABSTRACT: Environmental pollutants like PM_2.5 threaten hematopoietic homeostasis, yet how real-world exposure disrupts blood cell production, especially locally in the lung and systemically in the bone marrow (BM), remains poorly understood. Previous studies often used artificial particles or lacked mechanistic insights into systemic effects. Hypoxia-inducible factor-1alpha (HIF-1α) is essential for hematopoietic stem cell (HSC) maintenance. Herein, we utilized a real-ambient PM_2.5 exposure system and conducted a detailed characterization of hematopoietic and downstream immune cell populations in mice with myeloid lineage-specific knockout of HIF-1α (mHIF-1α^-/-) and their wild-type littermate controls. Our findings demonstrate that real-ambient PM_2.5 expos

SUBMITTER: Yu H 

PROVIDER: S-EPMC12709752 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature