The CM-aGPi Network in the Generation of Tics in Tourette Syndrome.

ABSTRACT:

Background

Tourette syndrome (TS) is a neurodevelopmental disorder characterized by intermittent involuntary, repetitive movements and vocalizations collectively referred to as tics. For participants with severe tics who are resistant to medication and behavioral therapy, deep brain stimulation (DBS) has emerged as a potential treatment. Suboptimal animal models and shortcomings in anatomical imaging have collectively hindered progress in understanding the neurophysiological basis of human tic generation.

Objectives

This study investigates the mechanisms underlying tic generation across two DBS targets with simultaneous recordings-the centromedian thalamus (CM) and anterior globus pallidus internus (aGPi)-and their interactions.

Methods

Six participants with TS underw

SUBMITTER: Lowor G 

PROVIDER: S-EPMC12710177 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature