Structure-Tailoring Cerium Nanozymes with Self-Cascade ROS Scavenging Catalysis Modulate the Microbiota-Gut-Joint Axis for Rheumatoid Arthritis Therapy.

ABSTRACT: Rheumatoid arthritis (RA) is closely associated with intestinal microbiota dysbiosis, highlighting the therapeutic potential of targeting the microbiota-gut-joint axis. Current interventions often overlook the cascade nature of reactive oxygen species (ROS) generation in driving intestinal and systemic inflammation. Herein, a valence-engineered CeO_X-based nanozyme with self-cascade catalytic activity is developed, mimicking sequential oxidase-superoxide dismutase-peroxidase functions to enable continuous ROS scavenging while minimizing oxygen generation. By precisely tuning Ce³⁺/Ce⁴⁺ ratios from 0.27 to 0.93 through Au deposition (0.23 wt.%→5.2 wt.%), Dual functionality is achieved: 1) enhanced oxygen vacancy generation (71.4%) for efficient ROS scavenging

SUBMITTER: Wang G 

PROVIDER: S-EPMC12713043 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature