The H4K20-mono-methyltransferase SETD8 promotes global accessibility of infecting herpes simplex virus genomes.

ABSTRACT: Epigenetic modulation of herpes simplex virus (HSV) immediate early (IE) genes is a critical parameter governing lytic infection, latency, and viral reactivation. Multiple factors, including epigenetic complexes associated with the cellular transcriptional coactivator HCF-1, modulate the state of HSV-1 chromatin. Although some aspects of HSV-1 chromatin biology have been elucidated, many epigenetic factors controlling HSV-1 chromatin accessibility and transcriptional regulation remain unknown. To identify novel epigenetic regulators of the initial stage of HSV-1 infection, an epigenetic chemical probe library was screened for molecules that impacted viral IE gene expression. This screen identified several epigenetic inhibitors that modulated IE expression. Notably, UNC0379, an inhibitor of

SUBMITTER: Arbuckle JH 

PROVIDER: S-EPMC12724366 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature