Individual and combined effects of indoor home exposures and ambient PM_2.5 during early life on childhood asthma in us birth cohort studies.

ABSTRACT:

Background

Children encounter multiple indoor and outdoor environmental exposures in early life. We assessed the independent effects of indoor home exposures and ambient particulate matter with an aerodynamic diameter ≤2.5 µm (PM_2.5) on early childhood asthma diagnosis.

Methods

We included 6,413 children born 1987-2016 from nine United States prospective birth cohorts from the Environmental Influences on Child Health Outcomes consortium, with complete covariate and outcome data. Exposures were (1) average ambient PM_2.5 levels during the first 3 years of life, and (2) indoor home exposures, including water damage/home dampness during infancy/childhood, dogs/cats at home during infancy, dust mite allergen during infancy/childhood. Asthma was defined as ca

SUBMITTER: Shiroshita A 

PROVIDER: S-EPMC12737862 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature