Development and External Validation of a Genetic Risk Score for Pain in Rheumatoid Arthritis.

ABSTRACT:

Objective

Several single-nucleotide polymorphisms (SNPs) have been associated with chronic pain syndromes. Our objective was to determine whether genetic variants are associated with pain and disease activity in rheumatoid arthritis (RA).

Methods

Participants were included from two independent RA cohorts: FORWARD (National Databank for Rheumatic Diseases, training data set) and the Veterans Affairs Rheumatoid Arthritis Registry (VARA; validation data set). Multivariable linear regression was used to estimate the relationship between cross-sectional pain scores and 36 fibromyalgia (FM)-associated SNPs in FORWARD. SNP alleles were summed and weighted by these regression coefficients to generate a genetic risk score (GRS) for pain for each participant in both cohorts. Linear re

SUBMITTER: McMenamin KJ 

PROVIDER: S-EPMC12750132 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature