Recombinant attenuated Salmonella vaccine promotes CD8⁺ T cell-dependent antitumor immunity via IFN-γ-induced IRF-1-mediated upregulation of IL-7.

ABSTRACT:

Background

Cancer is a leading cause of mortality worldwide, necessitating the development of novel therapeutic targets and strategies to prevent recurrence and metastasis. In this study, we aimed to evaluate whether a recombinant attenuated Salmonella vaccine (RASV) can stimulate antitumor immunity and prevent cancer progression in vivo.

Methods

We established a mouse model by transplanting cancer cells subcutaneously 4 weeks after oral RASV inoculation and analyzed bone marrow (BM) cells and tumor-infiltrated immune cells by flow cytometry. Further, we established a 4 T-1-induced metastatic cancer model to evaluate the RASV-mediated prevention of tumor metastasis.

Results

Adjuvant RASV significantly reduced tumor growth by enhancing CD8⁺ T cell activity a

SUBMITTER: Jeong JH 

PROVIDER: S-EPMC12752189 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature