TRPV1 deletion in male mice alters cardiomyocyte ultrastructure without affecting baseline cardiac function.

ABSTRACT: The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is implicated in various cardiovascular processes, including nociception, inflammation, and ischemia-reperfusion injury, yet its role in maintaining baseline cardiac structure and function remains unclear. To address this, we performed a bibliometric analysis of 331 publications (2004-2025) and conducted in vivo and ex vivo cardiac phenotyping of sedentary male TRPV1 knockout (TRPV1^⁻/⁻) and wild-type (TRPV1^⁺/⁺) mice (8-16 weeks). Echocardiography, patch-clamp electrophysiology, Ca²⁺ handling assays, mitochondrial function tests, and ultrastructural analyses were employed. Bibliometric mapping identified three major research clusters related to TRPV1 in cardiovascular science: ischemia-reperfusion injury, vas

SUBMITTER: Tessier N 

PROVIDER: S-EPMC12756331 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature