Proteinuria or Albuminuria as Markers of Kidney and Cardiovascular Disease Risk : An Individual Patient-Level Meta-analysis.

ABSTRACT:

Background

Urinary albumin-creatinine ratio (UACR) and urinary protein-creatinine ratio (UPCR) are both used in clinical practice to diagnose and monitor chronic kidney disease (CKD). Which measure exhibits stronger associations with clinical outcomes and whether this varies by patient characteristics are unknown.

Objective

To assess and compare the performance of UACR and UPCR across CKD-related clinical outcomes.

Design

Individual patient-level meta-analysis.

Setting

38 research and clinical cohorts.

Participants

148 994 participants with same-day measurements of UACR and UPCR.

Measurements

We quantified the associations of UACR and UPCR with subsequent clinical outcomes, including kidney failure and cardiovascular events, using Cox proportional

SUBMITTER: Heerspink HJL 

PROVIDER: S-EPMC12758604 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature