Risk factors for morphine-associated sedation in intravenous patient-controlled analgesia for postoperative pain.

ABSTRACT:

Background

Opioid-related oversedation is associated with respiratory depression and can lead to potentially catastrophic adverse events in hospitalized patients. This study aimed to investigate influential factors for postoperative sedation during morphine-based intravenous patient-controlled analgesia (IV-PCA).

Methods

We enrolled patients who received morphine-based IV-PCA for postoperative pain at a medical hospital between January 2020 and November 2022. The primary outcome was unintentional sedation within 72 h after surgery. The Observer Assessment of Alertness/Sedation Scale (OAA/S) was used to assess the sedation depth at 12-hour intervals. Multivariable logistic regression models were used to calculate the adjusted odds ratio (aOR) with 95% confidence interval (CI)

SUBMITTER: Wu JR 

PROVIDER: S-EPMC12764038 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature