Involvement of HemI, an ECF sigma factor, in hemin acquisition and antibiotic susceptibility in <i>Stenotrophomonas maltophilia</i>.

ABSTRACT:

Background

Hemin is a major source of iron for pathogens in infectious niches. The FecIRA-like surface signaling cascade is a common regulatory system for iron acquisition by pathogens. This system consists of a FecA-like TonB-dependent transporter (TBDT), a FecR-like inner membrane anti-sigma factor, and a FecI-like extracytoplasmic function (ECF) sigma factor. Beyond iron acquisition, FecIRA-like systems have been reported to regulate additional physiological processes. The known hemin acquisition system in Stenotrophomonas maltophilia includes HemA, a TBDT; HemU, an inner membrane transporter; and the TonB1-ExbB1-ExbD1a-ExbD1b complex, a multi-subunit motor that energizes HemA. Fur and HemP are the primary regulators involved in hemin utilization. In this study, we identi

SUBMITTER: Liao CH 

PROVIDER: S-EPMC12772443 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature