Genome-Wide Association Study for Glucocorticoid-Induced Ocular Hypertension.

ABSTRACT:

Purpose

To identify genetic variants associated with glucocorticoid (GC)-induced intraocular pressure (IOP) change using genome-wide association study (GWAS) and whole exome sequencing (WES) analyses.

Methods

530 participants from the Fluocinolone Acetonide in Diabetic Macular Edema (FAME) trials were analyzed, with replication performed in an independent cohort of 588 participants from the Mass Eye and Ear/Retina Health Center (MEE/RHC). All participants were exposed to GC, primarily via intravitreal injection. IOP was measured at baseline and serially within 6 months following GC exposure. GWAS and rare variant gene burden analyses were applied, adjusting for covariates.

Results

Genetic associations for maximal IOP change within 6 months after GC exposure were evalu

SUBMITTER: Lama J 

PROVIDER: S-EPMC12772669 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature