Treadmill exercise ameliorates atherogenesis and vascular inflammation in ApoE^-/- mice via circulating exosome-derived let-7c-5p.

ABSTRACT: Regular exercise training has been shown to significantly decrease atherosclerosis (AS) related mortality and hospitalization rates. Recent research has identified that circulating exosome-derived microRNAs (miRNAs) are closely related to the progression of AS through intercellular communication. But the role of exosome-derived miRNAs in exercise-mediated protection remains to be explored. This study proposes that exercise may ameliorate vascular dysfunction and plaque formation associated with AS by modulating the expression profile of exosomal miRNAs. In this study, ApoE^-/- mice were used and subjected to a ten-week treadmill exercise regimen to elucidate the molecular mechanisms by which exercise influences AS, specifically through alterations in exosomal miRNAs. The results

SUBMITTER: Guo W 

PROVIDER: S-EPMC12775415 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature