TMEM33 deletion potentiates anti-tumor CD8⁺ T cell immunity.

ABSTRACT: Improving responses to cancer immunotherapies requires deeper insight into the cellular mechanisms governing T cell-mediated anti-tumor immunity. TMEM33 is an endoplasmic reticulum-resident transmembrane protein enriched across multiple tumor types, with reported functions in anti-viral immunity as well as calcium and lipid homeostasis, yet its role in tumor immunosurveillance remains unknown. Using murine genetic models, we demonstrate that host TMEM33 constrains anti-tumor CD8⁺ T cell responses. Constitutive Tmem33 ^-/- mice exhibited delayed melanoma tumor growth and increased CD8⁺ T cell infiltration. Antigen-specific CD8⁺ compartments in tumors of Tmem33 ^-/- mice showed TCF-1⁺PD-1⁺

SUBMITTER: Jackson MT 

PROVIDER: S-EPMC12776282 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature