Murine implantation chamber formation precedes natural and artificial decidualization.

ABSTRACT: During pregnancy uterine stromal cells undergo a mesenchymal to epithelial cell transition termed decidualization. In humans initiation of decidualization occurs in the absence of an embryo resulting in a need to identify embryo-independent molecular cues that can initiate decidualization. Although, similar to humans, decidualization in the mouse can be induced in the absence of an embryo, whether an implantation event is prerequisite for such decidualization is not known. In this study using different models of estrogen-dependent implantation, including natural (embryo) and artificial (sesame oil, agarose only beads, and Concanavalin A coated agarose beads) we determined that implantation chamber formation precedes decidualization. We show that focal stimuli, including the embryo, Concana

SUBMITTER: Kumar HR 

PROVIDER: S-EPMC12776327 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature