Diagnostic Performance of the New Free Light Chain Ratio in Systemic Amyloidosis.

ABSTRACT:

Background

Detection of monoclonal components (MCs) using serum and urine immunofixation (IFE) and free light chain measurement is a critical early step in diagnosing cardiac amyloidosis. Patients with MCs are referred for biopsy-based diagnostic work-up. New reference ranges for the free light chain ratio (FLCR), adjusted for age and estimated glomerular filtration rate, have been proposed.

Objectives

The aim of this study was to compare the diagnostic performance of the new vs the conventional FLCR in patients with light chain (AL) amyloidosis and wild-type transthyretin (ATTRwt) amyloidosis.

Methods

The analysis included 1,705 patients with AL amyloidosis and 675 with ATTRwt amyloidosis.

Results

In the AL cohort, 44 patients (3%) had negative results on seru

SUBMITTER: Milani P 

PROVIDER: S-EPMC12790041 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature