The link between steady-state EEG and rs-fMRI metrics in healthy young adults: The effect of macrovascular correction.

ABSTRACT: To improve the clinical utility of resting-state fMRI (rs-fMRI), enhancing its interpretability is paramount. Establishing links with electrophysiological activities remains the benchmark for understanding the neuronal basis of rs-fMRI signals. Existing research, while informative, suffers from inconsistencies and a limited scope of rs-fMRI metrics (e.g., seed-based functional connectivity). Phenotypic variables like sex and age are suspected to obscure reliable fMRI-electroencephalography (EEG) associations. A major contributing factor to these inconsistencies may be the neglect of macrovascular correction in rs-fMRI metrics. Given that macrovascular contributions can inflate rs-fMRI connectivity and power, they may lead to misleading fMRI-EEG associations that do not reflect genuine neur

SUBMITTER: Zhong XZ 

PROVIDER: S-EPMC12797145 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature