Calciprotein crystallization time (T₅₀) and its association with surrogate cardiovascular disease risk markers in individuals with type 2 diabetes mellitus: the cross-sectional EARLY-HFpEF study.

ABSTRACT:

Background

Heart failure and peripheral artery disease (PAD) are the two most common cardiovascular diseases (CVD) in individuals with type 2 diabetes mellitus (T2DM). The T₅₀ calciprotein crystallization test measures the transformation of calciprotein particles type 1 (CPP1) into CPP2 in vitro and has been introduced as a low-cost biomarker for arterial calcification and CVD risk. We aimed to investigate the association between T₅₀ and (1) heart failure with preserved ejection fraction (HFpEF), (2) ankle-brachial index (ABI) as measure of PAD, (3) pulse wave velocity (PWV) as measure of central arterial stiffness and (4) arterial calcification in individuals with T2DM.

Methods

Cross-sectional data was used of 771 individuals with T2DM (64% men, 67 [63

SUBMITTER: Meer R 

PROVIDER: S-EPMC12801761 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature