Global prevalence and risk of gastroesophageal reflux disease symptoms in pregnancy: a systematic review and meta-analysis.

ABSTRACT:

Background

Gastroesophageal reflux disease (GERD), manifested by heartburn and regurgitation, is a common pregnancy complaint that significantly impairs quality of life. Reported prevalence varies widely, with differences observed across pregnancy trimesters. This first systematic review and meta-analysis synthesizing global data aimed to estimate the pooled prevalence and risk of GERD symptoms during pregnancy, including trimester-specific trends.

Methodology

Following PRISMA 2020 guidelines, a comprehensive literature search was conducted across MEDLINE/PubMed, EMBASE, Cochrane Library, and Google Scholar from 1 January 1975 to 10 July 2025. The protocol was registered in PROSPERO (CRD420251102794). Eligible studies included observational studies reporting the prevalence o

SUBMITTER: Khurmatullina AR 

PROVIDER: S-EPMC12801965 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature