Quantitative proteomic analysis identifies the unfolded protein response as a host pathway co-opted by ASFV to promote replication.

ABSTRACT: African swine fever (ASF), caused by the African swine fever virus (ASFV), is a highly contagious disease that affects pigs, resulting in substantial economic losses in the global pig industry. A comprehensive understanding of viral-host protein interactions can facilitate the discovery of therapies for viral infection. In this study, we employ a 4D label-free quantitative proteomics approach to profile a comprehensive protein dynamics analysis in ASFV-infected pigs, identifying over 6,000 proteins across multiple organs. Our results reveal coordinated interorgan responses characterized by inflammatory activation and interferon signaling in defense against ASFV. The protein-protein interaction network analysis uncovers ASFV-induced functional modules, including the unfolded protein respons

SUBMITTER: Zhang D 

PROVIDER: S-EPMC12802178 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature