Risk Factors of Sural Nerve Axonal Degeneration Using Clinically Relevant Thresholds in Context of Glucose Metabolism: The Maastricht Study.

ABSTRACT:

Introduction/aims

To study the association of risk factors with axonal degeneration, based on below-threshold sural nerve amplitudes, as a proxy for distal symmetric polyneuropathy (DSP). In particular, to assess the differential contribution of risk factors in diabetes status subgroups.

Methods

In 7242 participants of The Maastricht Study, a population-based cohort (aged 40 to 75 years, southern part of the Netherlands) focusing on type 2 diabetes (T2DM), associations between below-threshold sural nerve amplitudes (< 2.3 μV) and risk factors (diabetes status, demographics, anthropometrics, office systolic blood pressure, lifestyle, medication intake, and lipid profiles) were determined using logistic regression analysis in the total population and after stratification for n

SUBMITTER: Hodzelmans JJA 

PROVIDER: S-EPMC12803540 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature