Persistent urinary metabolic signatures in children with type 1 diabetes.

ABSTRACT: There are an estimated 3.7 million people with undiagnosed type 1 diabetes (T1D), living primarily in poor areas of the globe. Therefore, there is a need for non-invasive, affordable tests to provide accurate diagnosis despite the time post-disease onset and fasting state. Here, we studied persistent urinary T1D biomarkers that can be used to develop such tests. We analyzed the urine metabolomes of three independent cohorts of samples collected within 48 h (from Indiana University), and 1 year (from University of Colorado) and 1-10 years (6 years in average) (from Children's National Medical Center) post-diagnosis. Samples were submitted to gas chromatography-mass spectrometry and machine learning analyses to determine diagnostic metabolite panels. The data were also mapped into a metaboli

SUBMITTER: Nakayasu ES 

PROVIDER: S-EPMC12807541 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature