Morutamins A-L from <i>Morus alba</i> L. Root Bark with Inhibitory Effects on Epidermal Growth Factor Receptor and Toll-Like Receptor-Mediated NF-κB/AP‑1 Activation.

ABSTRACT: Morus alba L. root bark (MAR, "Sang-Bai-Pi" in traditional Chinese medicine) has been traditionally used for the treatment of inflammatory disorders. Phytochemical investigation of MAR yielded 11 new flavanones and one new chalcone (1-12, morutamins A-L), along with 27 known compounds (13-39). Their structures and absolute configurations were elucidated by combining HRESIMS and NMR analyses with DP4 and DP4+ probability calculations and ECD data. Among these, morutamin L (12) exhibited potent anti-inflammatory and immunomodulatory activities by inhibiting epidermal growth factor receptor and toll-like receptor agonist-induced NF-κB/AP-1 activation, which were explored through network pharmacology, molecular docking, and experimental verification. S

SUBMITTER: Le TT 

PROVIDER: S-EPMC12809818 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature