Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease.

ABSTRACT:

Objective

Lewy body disease (LBD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded α-synuclein in the brain. Neuroinflammation has long been implicated in LBD pathogenesis, and recent genetic studies in Parkinson's disease (a clinical manifestation of LBD) have shown consistent association with the human leukocyte antigen (HLA) gene complex. Here, we assessed whether variation in HLA alleles influences neuropathological burden in a neuropathologically-defined series of LBD cases.

Methods

We conducted a comprehensive analysis of HLA allelic variants in a cohort of 539 LBD cases of European descent from the Mayo Clinic brain bank. High-resolution whole-genome sequencing was used, and the HLA alleles of each sample were called using the HLA

SUBMITTER: Gavrielatos M 

PROVIDER: S-EPMC12814941 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature