Midlife and late-life population attributable fractions of risk factors for dementia in the United States: The Dementia Risk Prediction Project.

ABSTRACT:

Introduction

Dementia prevalence is associated with modifiable factors. We quantified the contribution of dementia risk factors in midlife (45-64 years) and late life (≥ 65 years) in the United States.

Methods

Data from six community-based cohorts in the Dementia Risk Prediction Project (DRPP) were used. We estimated risk factor prevalence using nationally representative data. Cohort-specific Cox regression models were used to estimate the association between modifiable risk factors and incident dementia in midlife and late life. Hazard ratios were pooled using meta-analysis then used to calculate population attributable fractions (PAFs) and potential impact fractions.

Results

Midlife and late-life risk factors contributed to 22.7% and 16.5% of total dementia cases, r

SUBMITTER: Li JM 

PROVIDER: S-EPMC12819166 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature