Associations of changes in frailty with multiple chronic diseases in middle aged and elderly adults.

ABSTRACT:

Background

Although the impact of baseline frailty status on chronic disease risks has been well-established, evidence on the associations between changes in frailty status and the incidence of new-onset chronic diseases remains limited.

Methods

A retrospective study of prospectively collected data from the China Health and Retirement Longitudinal Study (CHARLS) including 7 021 adults aged 45 years or older. Frailty status was evaluated by the Rockwood frailty index and classified as robust, pre-frail, or frail. Changes in frailty status were assessed by frailty status at baseline (2011) and the second survey (2013). All chronic diseases were identified by self-reported physician diagnosis. Cox proportional hazards regression models were used to estimate hazard ratios (HRs)

SUBMITTER: Yao T 

PROVIDER: S-EPMC12821276 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature