Integrative analysis and experiments to explore GAS1 as a prognostic target for ovarian cancer based on angiogenesis-related genes.

ABSTRACT:

Background

Intratumoral angiogenesis is crucial for the proliferation and metastasis of ovarian cancer. This study aims to comprehensively analyze the impact of angiogenesis-related genes on clinical outcomes, the immune landscape, and immunotherapy response in ovarian cancer.

Results

Through integrated analysis of transcriptomic data from The Cancer Genome Atlas and Gene Expression Omnibus databases, we identified two novel angiogenesis subtypes that exhibited significant differences in clinicopathological features, prognostic outcomes, and tumor microenvironment characteristics. An angiogenesis-based risk score was developed, which effectively stratified patients into distinct risk groups. These groups demonstrated divergent clinical prognosis, immune cell infiltration pat

SUBMITTER: Zhai L 

PROVIDER: S-EPMC12822331 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature