Spontaneous cervical artery dissection is associated with a distinct peripheral immune cell signature.

ABSTRACT:

Objectives

Despite being a major cause of ischemic stroke in young adults, the biological underpinnings of cervical artery dissection (CeAD) remain poorly defined. Recent data implicate immune activation as a potential contributor. We aimed to determine whether patients with CeAD display a distinct peripheral immune signature, which may provide insights into pathogenic inflammatory processes.

Methods

Peripheral blood mononuclear cells (PBMCs) from patients with spontaneous CeAD (n = 7 without and n = 11 with ischemic stroke) and ten age-matched healthy controls were analyzed via multi-color flow cytometry. Immune cell composition and activation markers were assessed, and sparse partial least squares discriminant analysis (sPLS-DA) was employed to identify CeAD-associated imm

SUBMITTER: Beuker C 

PROVIDER: S-EPMC12826460 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature