Comparative transcriptomic analysis of embryonic stem cells across mammalian species.

ABSTRACT: Pluripotency, the ability of cells to self-renew and differentiate into all body lineages, is vital for mammalian early development. This study presented a comprehensive comparative transcriptomic analysis of embryonic stem cells across multiple mammalian species, defining their progression through expanded/extended, naive, formative, and primed pluripotency states. Our findings revealed both conserved and species-specific mechanisms underlying pluripotency regulation. We also emphasized the limitations of existing state-specific markers and their limited cross-species applicability, while identifying de novo pluripotency markers. Despite variability in gene expression dynamics, gene co-expression networks showed remarkable conservation across species. Among pluripotency states, the

SUBMITTER: Fang Y 

PROVIDER: S-EPMC12828385 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature