Aptamer-engineered NIR-II Ru-doped carbon quantum dot nanozyme for photoacoustic imaging-guided synergistic photothermal and catalytic cancer therapy.

ABSTRACT: Carbon quantum dot (CQD)-based nanozymes have attracted growing interest for advanced biomedical applications owing to their superior catalytic activity, photostability, and biocompatibility. However, the rational design of a multifunctional nanoplatform that integrates active targeting, multimodal imaging, and synergistic therapy through a green and sustainable approach remains highly challenging. Herein, we report a facile and environmentally benign solvothermal strategy for the synthesis of ruthenium-doped CQD nanozymes (Ru-CQDs) functionalized with AS1411 aptamers and polyethylene glycol (PEG), denoted as Ru-CQDs-AS1411@PEG. This eco-friendly synthesis avoids toxic reagents and harsh conditions while yielding highly uniform and biocompatible nanozymes. The obtained Ru-CQDs-AS1411@PEG e

SUBMITTER: Hao Y 

PROVIDER: S-EPMC12831401 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature