Protective impact of circulating ω-3 PUFAs on sepsis susceptibility through PCSK9 variant: evidence from Mendelian randomization and animal experiments.

ABSTRACT:

Background

Polyunsaturated fatty acids (PUFAs), particularly ω-3 PUFAs, can improve sepsis prognosis. However, the relationship between the pre-infection levels of PUFAs and sepsis risk remains unclear.

Methods

We conducted a two-sample Mendelian randomization (MR) analysis using UK Biobank data to explore the causal association between circulating unsaturated fatty acids (UFAs) and sepsis susceptibility, complemented by a sepsis mouse model (cecal ligation and puncture, CLP) for validation.

Results

MR analysis revealed that ω-3 PUFAs (OR: 0.912, p = 0.005), ω-6 PUFAs (OR: 0.914, p = 0.036), total PUFAs (OR: 0.894, p = 0.003), and the PUFAs/MUFAs (monounsaturated fatty acids) ratio (OR: 0.927, p = 0.042) correlated with a reduced risk of se

SUBMITTER: Han Q 

PROVIDER: S-EPMC12834780 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature