Effect of the Icelandic Mutation APP^A673T in the Murine APP Gene on Phenotype of Line 66 Tau Mice.

ABSTRACT: The Icelandic mutation in the amyloid precursor protein (APP), APP^A673T, has been identified in Icelandic and Scandinavian populations and is associated with a significantly lower risk of developing Alzheimer's disease (AD). The introduction of the human APP^A673T form led to a reduction in amyloid β-protein (Aβ) production and tau pathology, but the effect of mouse APP^A673T on tau and Aβ pathology is not well studied. We have crossed line 66 (L66) tau transgenic mice that overexpress the P301S aggregation-prone form of tau with C57Bl6/J mice expressing a single-point mutation edited into the murine APP gene via CRISPR-Cas gene editing, known as mAPP^A673T. We have performed ELISA, histopathological, and behavioural analyses of heterozygous

SUBMITTER: Anschuetz A 

PROVIDER: S-EPMC12838599 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature