Molecular Dissection of Permanent vs. Reperfused Ischemia: Multi-Omics Divergence and Precision Therapeutic Implications.

ABSTRACT:

Objective

Cerebral ischemia-reperfusion injury (IRI) is a distinct pathological phase that differs from permanent ischemia (IR) in that it triggers secondary damage despite the restoration of blood flow. The primary objective of this study is to comprehensively characterize and compare the molecular signatures-such as differential gene expression, protein activation, and metabolic alterations-between IRI and IR. By doing so, we aim to identify key pathways and biomarkers that specifically drive IRI and IR pathology, thereby providing novel therapeutic targets to mitigate reperfusion-induced damage in stroke and related neurological conditions.

Methods

We employed an integrated transcriptomic and proteomic approach to compare a permanent ischemia model (IR, 24 h ischemia) wit

SUBMITTER: Shen Z 

PROVIDER: S-EPMC12840552 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature