HIIT-induced lactate/GPR81 signaling with dual branches converging on ERK1/2 contributes to hippocampal synaptic remodeling and memory improvement.

ABSTRACT: The remodeling of synapses in the hippocampus is intricately linked to processes of learning and memory. Research indicates that high-intensity interval training (HIIT) enhances cognitive functions reliant on the hippocampus in mice, although the specific receptor-mediated molecular pathways involved are not fully elucidated. Lactate, which is produced in significant amounts during HIIT, may function as a signaling agent in the brain through the lactate receptor G protein-coupled receptor 81 (GPR81), classified as a Gi-type G protein-coupled receptor. This investigation focused on the lactate/GPR81 pathway's contribution to synaptic remodeling in the hippocampus induced by HIIT and examined its downstream signaling characteristics. In vivo results demonstrated that HIIT led to an in

SUBMITTER: Bian X 

PROVIDER: S-EPMC12846946 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature