THBS3 Functions as a Novel Biomarker for Prognosis and Immunotherapeutic Response in Colorectal Cancer: An Integrative Analysis and Validation of the Thrombospondin Gene Family.

ABSTRACT:

Background

The THBS gene family plays key functions in various diseases; however, its specific roles in colorectal cancer (CRC) have not been systematically characterized.

Methods

Multi-omics data and online databases were used to analyze the mRNA expression levels of the THBS gene family in CRC and their correlations with clinicopathological features and survival. This analysis identified THBS3 as a potential oncogene closely linked with CRC progression. Then, the relationship between THBS3 expression and the immune landscape was assessed. Single-cell RNA sequencing analyzed THBS3 distribution in CRC subtypes. Additionally, GO, KEGG, and GSEA enrichment analyses investigated the mechanisms of THBS3 in CRC. Molecular docking identified anticancer compounds with high affinity

SUBMITTER: Jiang T 

PROVIDER: S-EPMC12847665 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature