The AHCY-adenosine complex rewires mRNA methylation to enhance fatty acid biosynthesis and tumorigenesis.

ABSTRACT: Methionine metabolism generates the substrate S-adenosylmethionine (SAM), which regulates epigenetic modifications crucial for various cellular processes, particularly tumorigenesis. However, whether methionine metabolism involves epigenetic mechanisms independent of SAM and what roles such mechanisms play in tumorigenesis remain unclear. We show here that the adenosylhomocysteinase (AHCY)-adenosine complex increases mRNA m⁶A levels in a non-global manner, promoting fatty acid synthesis and tumorigenesis. Adenosine increases mRNA m⁶A levels by binding to the methionine metabolism enzyme AHCY to form a complex, rather than depending on adenosine receptors. The AHCY-adenosine complex facilitates AHCY dimerization, with adenosine being crucial for dimer stability. AHCY d

SUBMITTER: Liao K 

PROVIDER: S-EPMC12848013 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature