Dataset Information

Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity.

ABSTRACT:

Importance

Tau positron emission tomography (PET) allows in vivo detection of neurofibrillary tangles, a core neuropathologic feature of Alzheimer disease (AD).

Objective

To provide estimates of the frequency of tau PET positivity and its associated risk of clinical outcomes.

Design, setting, and participants

Longitudinal study using data pooled from 21 cohorts, comprising a convenience sample of 6514 participants from 13 countries, collected between January 2013 and June 2024. Cognitively unimpaired individuals and patients with a clinical diagnosis of mild cognitive impairment (MCI), AD dementia, or other neurodegenerative disorders were included.