A prospective international multisite randomized controlled trial of water exchange with and without distal cap(s) in adenoma detection.

ABSTRACT:

Background

Interval cancers are linked to a low adenoma detection rate (ADR), prompting calls for benchmark-guided ADR performance improvement. Although water exchange and a straight cap (CAP) have been reported to independently improve ADR, the effects of Daisycuff^™ and Endocuff Vision^® remained unknown. We hypothesized that selected cap(s) could increase ADR and related water exchange outcomes.

Methods

Subjects were randomized to No cap, or CAP, Daisycuff^™ and Endocuff Vision^® at 7, 5 and 2 sites. The primary outcome was ADR. Outcomes were compared for No cap vs. the above randomized caps.

Results

Demographic and historic data revealed adequate randomization. Despite variations in site-specific pretrial ADR, the aggregated

SUBMITTER: Leung FW 

PROVIDER: S-EPMC12850690 | biostudies-literature | 2026 Jan-Feb

REPOSITORIES: biostudies-literature