Artemisia-derived carbon dots with excellent pharmacological activities and ROS scavenging for osteoarthritis treatment.

ABSTRACT: The pharmacological activities of traditional herbal medicine-derived carbon dots (THM-CDs) render them highly promising for applications in biomedicine. However, the interactions between THM-CDs and intracellular proteins have yet to be fully elucidated. Herein, inspired by the traditional vinegar-processing of Artemisia argyi (A. argyi), acetic acid-treated Artemisia argyi-derived carbon dots (AA-CDs) demonstrate excellent resistance to iron death via efficient ROS scavenging and Fe²⁺ chelating. Notably, multi-omics analysis uncovers a novel whereby AA-CDs directly target and stabilize heat shock protein A5 (HSPA5), thus preventing the degradation of glutathione peroxidase 4 (GPX4), a pivotal negative regulator of ferroptosis. Emerging evidence indicates that ferroptosis plays

SUBMITTER: Wang S 

PROVIDER: S-EPMC12853929 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature