Targeting SAA expression via siRNA mitigates preterm birth induced by maternal inflammation.

ABSTRACT:

Introduction

Placental inflammation is a major contributor to preterm birth (PTB), and there are currently few targeted strategies to prevent PTB and its associated adverse neonatal outcomes. Serum amyloid A (SAA), particularly the isoforms SAA1 and SAA2, are well-recognized inflammatory markers, but their functional roles in placental inflammation remain poorly defined.

Methods

Using a translational mouse model of sub-chronic maternal inflammation, we investigated the immune mechanisms and therapeutic potential of siRNA-mediated targeting of Saa2 (siSaa2). Placental expression patterns of SAA2 were examined in vivo, and macrophage responses to extracellular SAA2 were modeled in vitro using RAW264.7 cells to assess downstream P2X7R-dependent signaling and functional o

SUBMITTER: Lei J 

PROVIDER: S-EPMC12855142 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature