Oriented Multivalent Display Drives Consistent Serum Immunodominance to the Ebola Virus Glycoprotein.

ABSTRACT: Despite the vast diversity of B cell repertoires, serum antibody responses during viral infection often focus on a limited set of epitopesa phenomenon known as immunodominance. This inherent bias establishes a hierarchy of epitope responses, which often facilitates viral immune evasion and presents a major challenge for universal vaccine design. It remains unclear whether serum immunodominance is primarily driven by antigen-intrinsic properties or by the spatial constraints imposed by virion-bound antigen presentation. Here, using Ebola virus glycoprotein (GP) as a model system, we found that trimeric GP elicited varied epitope hierarchies between individual animals during primary immunization. In contrast, multivalent GP presentation on either a vesicular stomatitis virus or ferritin nan

SUBMITTER: Zheng C 

PROVIDER: S-EPMC12856675 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature